Sleep

Red Light and the Sleep Quality and Endurance Performance of Chinese Female Basketball Players Source

Anti aging

A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase. Studies showed significant increase in collagen leading to the reduction of wrinkles and loose skin. Source

Skin Rejuvenation

Bhat J, Birch J, Whitehurst C, and Lanigan SW. 2005. A single blinded randomised controlled study to determine the efficacy of Omnilux Revive facial treatment in skin rejuvenation. Lasers Med Sci , 20: 6–10 20 min treatments three times a week for three weeks.
ABSTRACT ONLY Source 

Calderhead RG, Kubota J, Trelles MA, and Ohshiro T. 2008. One mechanism behind LED phototherapy for wound healing and skin rejuvenation: Key role of the mast cell. Laser Ther, 17: 141–148 830 nm 4.3 treatments per injury, range 2 – 6. Source

Lee MW. 2002. Combination visible and infrared lasers for skin rejuvenation. Semin Cutan Med Surg , 21: 288–300.( 532 nm and 1064 nm 3 to 6 times at monthly intervals) Source

Compiled by Dahlia Health LLC. 07/21
Lee SY, Park KH, Choi JW, Kwon JK, Lee DR, Shin MS, Lee JS,You CE, Park MY. 2007a. A prospective, randomized, placebo controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: Clinical,profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. J Photochem
Photobiol B , 88: 51–67.(830nm and 633nm twice a week for four weeks)  Source

Russell BA, Kellett N, and Reilly LR. 2005. A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation. J Cosmet Laser Ther 7: 196–200. (633 nm and 830 nm nine light therapy treatments) Source

Skin Tightening

The treated subjects experienced significantly improved skin complexion and skin feeling, profilometrically assessed skin roughness, and ultrasonographically measured collagen density. Source

Neira R, Arroyave J, Ramirez H, Ortiz CL, Solarte E, Sequeda F, and Gutierrez MI. Fat liquefaction: Effect of low-level laser energy on adipose tissue (635 nm 6 min irradiation time) Source

Caruso-Davis MK, Guillot TS, Podichetty VK, Mashtalir N, Dhurandhar NV, Dubuisson O, et al. Efficacy of low-level laser therapy for body contouring and spot fat reduction. (635–680 nm 30 min twice a week for 4 weeks). Source

Cellulite Reduction

Reduction in thigh circumference and improvement in the appearance of cellulite with dual-wavelength, low-level laser energy and massage. Michael H. Gold, Khalil A. Khatri, Kelley Hails, Robert A. Weiss & Nathalie Fournier (650 nm and 915 nm 83 subjects). Source

Sasaki GH, Oberg K, Tucker B, and Gaston M. The effectiveness and safety of topical PhotoActif phosphatidylcholine-based anti-cellulite gel and LED (red and near-infrared) light on Grade II-III thigh cellulite: a randomized, double-blinded study. J Cosmet Laser Ther, 2007; 9(2): 87–96. (660 nm and 950 nm 3 months.) Twice weekly, each thigh was exposed for a 15-minute treatment with LED light for a total of 24 treatments Source

Study of the Effect of Low Level Laser Light Therapy on Reducing the Appearance of Cellulite in the Thighs and Buttocks -532nm n/a. Source

Low-level laser therapy (LLLT) does not reduce subcutaneous adipose tissue by local adipocyte injury but rather by modulation of systemic lipid metabolism. (650nm 6 treatments 2-3 days apart) Source

Compiled by Dahlia Health LLC. 07/21
Efficacy of a multiple diode laser system for body contouring. (532nm 6 treatments, three times per week for 2 weeks). Source

Skin/Acne

Aziz-Jalali MH, Tabaie SM, and Djavid GE. 2012. Comparison of red and infrared low-level laser therapy in the treatment of acne vulgaris. Indian J Dermatol , 57: 128–130. (630 and 890nm twice in a week for 12 sessions)
Source

Cunliffe WJ and Goulden V. 2000. Phototherapy and acne vulgaris. Br J Dermatol, 142: 855–856. Source

Goldberg DJ and Russell BA. 2006. Combination blue (415 nm) and red (633 nm) LED phototherapy in the treatment of mild to severe acne vulgaris. J Cosmet Laser Ther, 8: 71–75. (415 nm and 633nm 20 min per session, 8sessions, two per week 3 days apart) Source

Lee SY, You CE, and Park MY. 2007b. Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV. Lasers Surg Med , 39: 180–188. (415 nm and 633nm twice a week for 4 weeks) Source

Lloyd JR and Mirkov M. 2002. Selective photothermolysis of the sebaceous glands for acne treatment. Lasers Surg Med , 31: 115–120. Source

Papageorgiou P, Katsambas A, and Chu A. 2000. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br J Dermatol , 142: 973–978. (415 nm and 633nm daily for 15 min for 12weeks) Source

Railan D and Alster TS. 2008. Laser treatment of acne, psoriasis, leukoderma, and scars. Semin Cutan Med Surg , 27: 285–291. Source

Rotunda AM, Bhupathy AR, and Rohrer TE. 2004. The new age of acne therapy: Light, lasers, and radiofrequency. J Cosmet Laser Ther, 6: 191–200. Source

Sadick NS. 2008. Handheld LED array device in the treatment of acne vulgaris. J Drugs Dermatol, 7: 347–350 415 nm and 633nm 8 20-minute (blue) or 30- minute (red) alternated light treatments, self- administered by a handheld unit over a period of 4 weeks. Source

Seaton ED, Mouser PE, Charakida A, Alam S, Seldon PM, and Chu AC. 2006. Investigation of the mechanism of action of nonablative pulsed-dye laser therapy in photorejuvenation and inflammatory acne vulgaris. Br J Dermatol, 155: 748–755. Source

Compiled by Dahlia Health LLC. 07/21
Stathakis V, Kilkenny M, and Marks R. 1997. Descriptive epidemiology of acne vulgaris in the community. Australas J Dermatol , 38: 115–123 n/a n/a. Source

Psoriasis

Ablon G. 2010. Combination 830-nm and 633-nm light emitting diode phototherapy shows promise in the treatment of recalcitrant psoriasis: Preliminary findings. Photomed Laser Surg, 28: 141–146. (830-nm and 633-nm two 20-min sessions over 4 or 5 weeks, with 48 h between
sessions) Source

Asawanonda P, Anderson RR, Chang Y, and Taylor CR. 2000. 308-nm excimer laser for the treatment of psoriasis: A doseresponse study. Arch Dermatol , 136: 619–624. 308-nm 1, 2, 4, and 20 treatments. Source

Berns MW, Rettenmaier M, McCullough J, Coffey J, Wile A, Berman M, DiSaia P, and Weinstein G. 1984. Response of psoriasis to red laser light (630 nm) following systemic injection of hematoporphyrin derivative. Lasers Surg Med , 4: 73–77. 630 nm. Source

De Leeuw J, Van Lingen RG, Both H, Tank B, Nijsten T, and Martino Neumann HA. 2009. A comparative study on the efficacy of treatment with 585 nm pulsed dye laser and ultraviolet B-TL01 in plaque type psoriasis. Dermatol Surg , 35: 80–91 585 nm n/a. Source

Gattu S, Rashid RM, and Wu JJ. 2009. 308-nm excimer laser in psoriasis vulgaris, scalp psoriasis, and palmoplantar psoriasis. J Eur Acad Dermatol Venereol , 23: 36–41. 308-nm n/a source

Trehan M and Taylor CR. 2002. Medium-dose 308-nm excimer laser for the treatment of psoriasis. J Am Acad Dermatol, 47: 701–708 308-nm (3 times per week for up to 8 weeks) source

Finlay AY, Khan GK, Luscombe DK, and Salek MS. 1990.Validation of sickness impact profile and psoriasis disability index in psoriasis. Br J Dermatol , 123: 751–756. n/a n/a source

Scars

Phototherapy applied after inguinal-hernia surgery was effective in preventing the formation of keloids. In addition, Phototherapy resulted in better scar appearance. source

Barolet D and Boucher A. 2010. Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids: A case series. Lasers Surg Med , 42: 597–601. 805 nm 30 days source

Compiled by Dahlia Health LLC. 07/21
Bouzari N, Davis SC, and Nouri K. 2007. Laser treatment of keloids and hypertrophic scars. Int J Dermatol , 46: 80–88. 585 nm source

Railan D and Alster TS. 2008. Laser treatment of acne, psoriasis, leukoderma, and scars. Semin Cutan Med Surg , 27: 285–29 source

Phototherapy applied after inguinal-hernia surgery was effective in preventing the formation of keloids. In addition, Phototherapy resulted in better scar appearance. source

Vitiligo

Lan CC, Wu CS, Chiou MH, Chiang TY, and Yu HS. 2009. Lowenergy heliumneon laser induces melanocyte proliferation via interaction with type IV collagen: Visible light as a therapeutic option for vitiligo. Br J Dermatol, 161: 273–280. 632.8 nm n/a source

Lan CC, Wu CS, Chiou MH, Hsieh PC, and Yu HS. 2006. Lowenergy heliumneon laser induces locomotion of theimmature melanoblasts and promotes melanogenesis of the more differentiated melanoblasts: Recapitulation of vitiligo repigmentation in vitro. J Invest Dermatol , 126: 2119–2126 632.8 nm n/a source

Yu HS. 2000. Treatment of vitiligo vulgaris with helium-neon laser. MB Derma 35: 13–18. 632.8 nm n/a source

Fat Loss/ Contouring

Independent evaluation of low-level laser therapy at 635 nm for non-invasive body contouring of the waist, hips, and thighs source

Body contouring using light therapy source

Light therapy for fat layer reduction source

Efficacy of low-level laser therapy for body contouring source

Light therapy as a non-invasive approach for body contouring source

Light therapy as a non-invasive approach for body contouring
Compiled by Dahlia Health LLC. 07/21 source

Bone Healing

Phototherapy promoted bone healing. source

Phototherapy can promote bone healing and bone mineralization and thus may be clinically beneficial in promoting bone formation in skeletal defects. source

Pain Relief and Inflammation

In response to stimuli in the microenvironment, macrophages adopt either the M1 or M2 phenotype to coordinate the tissue repair process. Photobiomodulation (PBM) plays an important role in the modulation of acute inflammation, including cellular influx, macrophage polarization, and the release of inflammatory mediators. source

Alves, A. C., Vieira, R., Leal-Junior, E., Dos Santos, S., Ligeiro, A. P., Albertini, R., Junior, J., and De Carvalho, P. 2013. Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation. Arthritis Res Ther, 15, R116. 808 nm source

Bortone, F., Santos, H. A., Albertini, R., Pesquero, J. B., Costa, M. S., and Silva, J. A., Jr. 2008. Low level laser therapy modulates kinin receptors mRNA expression in the subplantar muscle of rat paw subjected to carrageenan induced inflammation. Int Immunopharmacol, 8, 206–210. (660 or 684 nm) source

Ferreira, D., Zangaro, R., Villaverde, B., Cury, Y., Frigo, L., Piccolo, G., Longo, I., and Barbarosa, D. 2005. Analgesic effect of He-Ne (632.8 nm) low-level laser therapy on acute inflammation pain. Photomed Laser Surg, 23, 177–181. 632.8 nm n/a Source

Laraia, E. M., Silva, I. S., Pereira, D. M., Dos Reis, F. A., Albertini, R., De Almeida, P., Leal Junior, E. C., and De Tarso Camillo De Carvalho, P. 2012. Effect of low-level laser therapy (660 nm) on acute inflammation induced by tenotomy of Achilles tendon in rats. Photochem Photobiol, 88, 1546–1550. (660 nm 6, 24 and 72 h) Source

Pallotta, R. C., Bjordal, J. M., Frigo, L., Leal Junior, E. C., Teixeira, S., Marcos, R. L., Ramos, L., De Moura Messias, F., and Lopes-Martins, R. A. 2011. Infrared (810 nm) low-level laser therapy on rat experimental knee inflammation. Lasers Med Sci , 27(1), 71–78. 810-nm n/a source

Prianti, A. C., Jr., Silva, J. A., Jr., Dos Santos, R. F., Rosseti, I.B., and Costa, M. S. 2014. Low-level laser therapy (LLLT)reduces the Cox-2 mRNA expression in both subplantar and total brain tissues in the model of peripheral inflammation induced by administration of carrageenan. Lasers Med Sci , 29(4), 1397–1403. 660 nm. n/a source

Rees, J. D., Stride, M., and Scott, A. 2013. Tendons: Time to revisit inflammation. Br J Sports Med , 48(21), 1553–1557. n/a n/a source

Soriano, F., Campana, V., Moya, M., Gavotto, A., Simes, J., Soriano, M., Soriano, R., Spitale, L., and Palma, J. 2006. Photobiomodulation of pain and inflammation in microcrystalline arthropathies: Experimental and clinical results. Photomed Laser Surg, 24, 140–150. (633 nm daily for 10 consecutive days) source

Pain Relief

Alayat, M. S., Atya, A. M., Ali, M. M., and Shosha, T. M. 2013. -Long-term effect of high-intensity laser therapy in the treatment of patients with chronic low back pain: A randomized blinded placebo-controlled trial. Lasers Med Sci , 29(3): 1065–1073. n/a n/a source

Basford, J., Sheffield, C., and Harmsen, W. 1999. Laser therapy: A randomised, controlled trial of the effects of low intensity Nd:Yag laser irradiation on musculoskeletal back pain. Arch Phys Med Rehabil, 80, 647–652. 1064nm 90 seconds at eight symmetric points along the lumbosacral spine three times a week for 4 weeks source

Walker, J. 1983. Relief from chronic pain by low power laser irradiation. Neurosci Lett, 43, 339–344. source

Bingol, U., Altan, L., and Yurtkuran, M. 2005. Low-power laser treatment for shoulder pain. Photomed Laser Surg, 23, 459–464.(904 nm 10 sessions during a period of 2 weeks) source

Ceylan, Y., Hizmetli, S., and Silig, Y. 2004. The effects of infrared laser and medical treatments on pain and serotonin degradation products in patients with myofascial pain syndrome. A controlled trial. Rheumatol Int, 24, 260–263. (810nm once a day for 10 consecutive days) source

Chow, R. T., Lopes-Martins, R., Johnson, M., and Bjordal, J. M. 2009. Efficacy of low-level laser therapy in the management of neck pain: A systematic review and metaanalysis of randomised, placebo and active treatment controlled trials. Lancet, 374, 1897–1908. source

Ferreira, D., Zangaro, R., Villaverde, B., Cury, Y., Frigo, L., Piccolo, G., Longo, I., and Barbarosa, D. 2005. Analgesic effect of He-Ne (632.8 nm) low-level laser therapy on acute inflammation pain. Photomed Laser Surg, 23, 177–181 632.8 nm n/a source

Fiore, P., Panza, F., Cassatella, G., Russo, A., Frisardi, V.,Solfrizzi, V., Ranieri, M., Di Teo, L., and Santamato, A. 2011. Short-term effects of high-intensity laser therapy versus ultrasound therapy in the treatment of low back pain: A randomized controlled trial. Eur J Phys Rehabil Med, 47, 367–373. n/a (15 treatment sessions,during 3 weeks) source

Gworys, K., Gasztych, J., Puzder, A., Gworys, P., and Kujawa, J. 2012. Influence of various laser therapy methods on knee joint pain and function in patients with knee osteoarthritis. Ortop Traumatol Rehabil, 14, 269–277 (810 nm 1 or 2 treatments) source

Venezian, G. C., Da Silva, M. A., Mazzetto, R. G., and Mazzetto, M. O. 2010. Low Level laser effects on pain to palpation and electromyographic activity in TMD patients: Adouble-blind, randomized, placebo-controlled study. Cranio, 28, 84–91. 780 nm twice a week (four weeks). Forty-eight (48)patients source

Mckibbin, L. S., and Downie, R. 1991. Treatment of postherpetic neuralgia using a 904 nm (infrared) low incident energy laser: A clinical study. Laser Ther, 3, 35–39.8 nm, (780nm, 830 nm,904 nm -5 trials, 188 participants) source

Namazawa, R., Kemmotsu, O., Otsuka, H., Kakehata, J.,Hashimoto, T., Tamagawa, S., and Maumi, T. 1996. The role of laser therapy in intensive pain management of postherpetic neuralgia. Laser Therapy, 8, 143–148. n/a (5 minutes and 6 seconds,15 consecutive days) source

Trelles, M., Mayayo, E., Miro, L., Rigau, J., Baudin, G., and Calderhead, R. 1989. The action of low reactive laser therapy(LLLT) on mast cells: A possible pain relief mechanism examined. Laser Ther, 1, 27–30. 488, 514.5, 532, 633, 638, 670, 830, 880,980or 1064 nm n/a source

Umegaki, S., Tanaka, Y., Hisakai, M., and Koshimoto, H. 1989. Effectiveness of low-power laser therapy on low-back pain: Double-blind comparative study to evaluate the analgesic effect of low power laser therapy on low back pain. Clin Rep, 23, 2838–2846. n/a n/a source

Venezian, G. C., Da Silva, M. A., Mazzetto, R. G., and Mazzetto, M. O. 2010. Low Level laser effects on pain to palpation and electromyographic activity in TMD patients: A double-blind, randomized, placebo-controlled study. Cranio, 28,84–91. ( 780 nm twice a week (four weeks), Forty-eight (48)patients source

Photobiomodulation (PBM) also known as low-level level laser therapy is the use of red and near-infrared light to stimulate healing, relieve pain, and reduce inflammation. source

Phototherapy effectively relieves pain of various etiologies; making it a valuable addition to contemporary pain management armamentarium. source

Efficacy of phototherapy in the management of neck pain. source

This study shows that phototherapy reduces pain after treatment in acute and chronic neck pain. source

Phototherapy reduces pain immediately after treatment in acute neck pain and up to 22 weeks after completion of treatment in patients with chronic neck pain source

Analyzing the analgesic effect of phototherapy showing it as a treatment of myofascial pain
syndrome. source

Phototherapy for acute neck pain with radiculopathy: a double-blind placebo controlled randomized study. source

The results of this study show better improvement in acute LBP treated
with Phototherapy. source

Phototherapy is beneficial for pain in myofascial pain syndrome. source

Phototherapy seemed to be an effective method in reducing pain and functional disability in the therapy of chronic low back source

A practice-based study of patients with acute and chronic low back pain. source

In chronic low back pain, phototherapy combined with exercise is more beneficial than exercise alone in the long term. source

Comparison of 3 physical therapy modalities for acute pain in lumbar disc herniation measured by clinical evaluation and magnetic resonance imaging. source

Phototherapy can be beneficial for the reduction of postoperative pain. source

Wound healing

Cell viability, free radical-induced oxidative stress, NF-κB activation, nitric oxide release, mitochondrial respiration, and wound healing repair were assessed in human endothelial cells source

Findings indicated a beneficial effect of laser stimulation on wound healing. source

Low level light therapy by LED of different wavelength induces angiogenesis and improves ischemic wound healing. 470 and 629 5 treatments, 5 consecutive days, 10 min applications source

Role of low-level laser therapy in neurorehabilitation (670 nm 1 time 20 minutes) source

Photobiomodulation by laser therapy rescued auditory neuropathy induced by ouabain. source

The mechanistic basis for photobiomodulation therapy of neuropathic pain by near infrared laser light. (808 nm 1 time 120 seconds) source

A comparative study of red and blue light-emitting diodes and low-level laser in regeneration of the transected sciatic nerve after an end to end neurorrhaphy in rabbits. LLL (680 nm), red LED (650 nm), and blue LED (450 nm) 14 treatments one per day for 14 days source

Photobiomodulation Triple Treatment in Peripheral Nerve Injury: Nerve and Muscle Response. source

Regeneration of specific nerve cells in lesioned visual cortex of the human brain: an indirect evidence after constant stimulation with different spots of light. (656nm) 656, 525, 578 and 450 n/a source

The effect of photobiomodulation on chemotherapy-induced peripheral neuropathy: A randomized, sham controlled clinical trial. source

Analysis of the variation in low-level laser energy density on the crushed sciatic nerves of rats: a morphological, quantitative, and morphometric study. (780nm) 780 n/a source

Compiled by Dahlia Health LLC. 07/21 Effect of photobiomodulation therapy (808 nm) in the control of neuropathic pain in mice 808 n/a source

Effect of Laser Photobiomodulation with Gradual or Constant Doses in the Regeneration of Rats’ Mental Nerve After Lesion by Compression. (808nm) 808 20 treatments. source

Light promotes regeneration and functional recovery and alters the immune response after spinal cord injury. (810nm) 810 source

Promotion of regenerative processes in injured peripheral nerve induced by low-level laser therapy. (901nm) 901 10 treatments source

Neuropeptide expression and morphometric differences in crushed alveolar inferior nerve of rats: Effects of photobiomodulation. (904nm 904 11 treatments) source

Findings indicated a beneficial effect of laser stimulation on wound healing. source

Phototherapy is an effective tool for promoting wound repair. source

Shows the efficacy in post-operative wounds. source

Phototherapy is an effective therapeutic modality for wound healing. source

Phototherapy effects on wound healing. source

In addition to accelerated wound healing, the main advantages of Phototherapy with injuries include prevention of side effects of drugs, significantly accelerated functional recovery and earlier return to work. source

Phototherapy resulted in enhanced healing. source

This NASA research shows that Phototherapy will greatly enhance the natural wound healing process, and more quickly return the patient to a pre injury/illness level of activity. source

Hawkins, D., Houreld, N., and Abrahamse, H. (2005). Low level laser therapy (LLLT) as an effective therapeutic modality for delayed wound healing. Ann. N Y Acad. Sci., 1056, pp.486–493 source

Compiled by Dahlia Health LLC. 07/21 Hopkins, J.T., McLodat, T.A., Seegmiller, J.G., and Baxter, G.D. (2004). Low-level laser therapy facilitates superficial wound healing in humans: A triple-blind, sham-controlled study. J. Athl. Train. , 39(3), pp. 223–229 n/a 2 minutes, 5 seconds source

Lucas, C., Stanborough, R.W., Freeman, C.L., and DeHaan, R.J. (2000). Efficacy of low-level laser therapy on wound healing in human subjects: A systematic review. Lasers Med. Sci. , 15, pp. 84–93 904 nm 125s source

Saltmarche, A.E. (2008). Low level laser therapy for healing acute and chronic wounds: The Extendicare experience. Int.Wound J ., 5, pp. 351–360 source

Hair

Novel Approach to Treating Androgenetic Alopecia in Females With Photobiomodulation (Low-Level Laser Therapy). 650 60 treatments source

The growth of human scalp hair mediated by visible red light laser and LED sources in males. (655 60 treatments, every other day, 25 minute treatment) source

The growth of human scalp hair in females using visible red light laser and LED sources.656 (60 treatments, every other day, 25 minute treatment) source